Chronic AIHA is found more commonly in the outlier age groups including kids less than 2 and teenagers. Primary AIHA includes warm reactive, cold reactive and paroxysmal cold hemoglobinuria. Secondary AIHA includes those resulting from systemic autoimmune diseases, malignancy and medications and are discussed below: IgG mediated “warm reactive”. Sep 20, 2021 · Known associations with autoimmune hemolytic anemia (AIHA) include lymphoproliferative neoplasms, autoimmune conditions, and viral infections. There are a few case reports that implicate a potential relationship between COVID-19 and either warm or cold AIHA. We present the case of combined warm and cold AIHA in the setting of COVID-19.. Lesson on Autoimmune Hemolytic Anemia (Warm, Cold, and Paroxysmal Cold Hemoglobinuria): Clinical features, Laboratory findings, Signs and Symptoms, Diagnosis.... Hemolytic Anemia Approach. - Prove anemia: o Suspect: § Rapid Hb drop, no bleeding, increased retics, Plasma-free Hb incr, elevated bilirubin ( unconj ), incr urobilinogen , AST (and not ALT), LDH, low or absent haptoglobin , urinary hemosiderinuria, coombs test. § High LDH and low haptoglobin 90% sensitive for hemolysis. - Etiology. o.